Karen Sisco is an American crime drama television series starring Carla Gugino in the title role. The series was created by novelist Elmore Leonard, based on a character who had appeared in several of his written works, as well as one film adaptation, 1998's Out of Sight. The series debuted on October 1, 2003 on ABC, and was canceled in November after 7 episodes aired, with the final 3 episodes burned off in late-night during the spring of 2004.

As a U.S. Deputy Marshal, based on Miami, Florida's Gold Coast, Karen must deal with the underbelly of South Beach nightlife and Palm Beach high life while tracking down fugitives. She also struggles to win the respect of her fellow officers. Karen occasionally gets advice from her father, a retired Miami police officer turned private investigator, who is Karen’s confidant, counselor, and confessor. The show ran in the same time slot as the 14th season of NBC's Law & Order, drawing less than half the audience during its opening weeks, losing audience until it drew less than one third the viewership of Law & Order before it was cancelled.

In 2012, Gugino reprised her role, now as an Assistant Director with the Marshals Service, in a third season episode of Justified. In 2013, TV Guide included the series in its list of 60 shows that were "Canceled Too Soon". In 2012, Gugino reprised her role, now an Assistant Director with the Marshals Service, in a third season episode of Justified.